Short answer = YES, long answer is that you get high stresses on the output diodes at 40V
also - better stick to 50kHz if you ain't done this before
10V to 100V is a 10 to one step up ( plus a bit for losses ) so 150V diodes if a bridge output
now you run at 40V in, Vout = 400V peak from the Tx, then LC filtered to get the average given by the pwm
so 600V diodes needed, 6A or 8A each for your 4A out assuming full bridge into LC
1200V diodes needed for centre tap output from Tx