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Hi,

from my experience: everything below 10uV becomes difficult.

Depending on range, frequency response, measurement timing ... and so on one could go quite below 1uV .. But I see no change to get below 100nV with reasonable effort.

This is 0.5ppm? it´s difficult to detect from 0nV to 50nV ...(without 100mV offset) but in the rane you say .. even the REFERENCE and it´s drift plays a major role.

Noise, thermcouple effects, mechanical stress on a PCB ... all will cause more error than 50nV.

Again: it all depends on the complete specifications.

Klaus