Hi,
So if we assume 12MHz ... and you don´t want to get much impedance problems, then going to 100MHz should be well enough.
So if the 5th harmonic (60MHz) which has only 20% of the fundamental amplitude on asquare wave... then the "mismatch problem" shouldn´t harm, even with FR4 material.
But 12MHz is rather low frequency. ... and means signal wavelength of maybe 40m.
So when we say (rule of thumb) impedance matters maybe down to 1/10 to 1/20 of wavelength, then we still ar at least at 2m. I guess your traces are much shorter. Thus the whole impedance problem is not that critical.
So my recommendation:
Design your traces according specified impedance and you are safe.
Relax. Don´t overcomplicate a 12MHz interface.
Klaus