That's a good question. I'm not an expert in the matter, but the way I interpret the rules, there are no power level limitations in ISM bands. They are designed for industrial, scientific and medical applications which use very strong RF transmitters such as for example microwave ovens. Your microwave oven emits about 800W at 2.45 GHz, so any limitation of power levels in ISM bands would de facto make microwave ovens unusable.
The downside is that devices operating in ISM bands need to be interference tolerant for the same reason.