This circuit shows no body terminals and you probably need to
deal with that; 15V Vgb is going to pop any 5V transistor that
doesn't have a high voltage independently bias-able well. I'd
bet this was done on an SOI technology.
The PMOS cross coupled pair has to be made weaker than
the whole stack. You may elect to use resistors for this,
they will have a more consistent current limiting.
Aside from this, sizing plays in prop delay primarily, and
the transition currents (dynamic Idd).
Managing the bias rails so that your level shifter stack
consistently has enough grunt to flip over the PMOS
pair, wants some attention. So does the initialization of
the high side, when the high side rail does not provide
enough headroom for all of those stacked VTs to pull
usable current. Power-up in unknown state is your likely
outcome, otherwise, along with misbehavior during the
supply ramp-up time.