Settling time is a general parameter and usually it has a sense when the information of accuracy level for settling is provided too.
The division between small and large signal response is a convention, but it is simple and clear.
Small signal approximation is a linearization of the device. So, you can look on the response, and say that as long as the response is following exponential function, it is small signal. When it starts to be a linear function of time, it is large signal response.
The more precise answer is to look on the input and output voltages in respect to operating points of the transistor.
In case of differential pair you can check for which input voltage range, the differential transconductance is constant (or differential current of diff-pair is linear). In the extreme case (no degeneration of diff pair and deep weak inversion, current of MOST diff pair can be approximated to well-known formula for BJT diff-pair), the relation is proportional to tanh(2Vin/Vt), when Vt is a thermal voltage - it can gives you limit for input voltage to keep diff-pair linear. This value is small and we can say that with very good accuracy it is 0.2×Vt (≈5mV). For MOST it is a bit higher limit, however hard to calculated due to non-elementary I-V relationship of MOST.
From the other hand, the OPAMP use to working with closed loop and some gain. For low gain configuration it is not a big deal to not taking care of output amplitude, when input signal is small enough. However, for high gain we can imagine, that 5mV input signal can generate 500mV output step (what can be close to saturation of such OPAMP with below 1V supplies). Here we need to look on the DC OPs of output current sources (or source follower stage if exists), to keep them on the output I-V characteristic point with no large changes in the current (it is relatively easy when are saturated).
The time parameters of the input step are easy to guess.
Input step signal should imitate Heaviside function, so it rise/fall time should be close to 0 in comparison to rise/fall time of response - your OPAMP UGF is 100MHz=628Mrad/s, it means it rise/fall time is ≈1/(2.2×UGF(rad/s))≈720ps, so 10ps should not affect response timing.
The minimum step duration is again simple - 95% is achieved after 3/UGF(rad/s), 99.4% after 5/UGF(rad/s), 10bit accuracy after 10.5/UGF(rad/s). So, depending on your needs you can set the optimum step duration.
The period could be infinity, because you need only one rising and one falling edge.