Yes you can. You can send the data to all the receivers, which can all be assigned different IDs or addresses. The transmitter first sends the ID/address and then the data. So, the receiver can check if the data has been sent for it or not. You can also use a third pin for something like chip select. But this would require an additional pin for each receiver.
There's no problem with the 2 PICs running off different clock frequencies. Just make sure they use the same UART configuration.