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The RS-422 specification recommends twisted pair cable. I recommend erring on the safe side and using shielded cable. Shielded cable is only slightly more expensive than unshielded. It can be difficult to quantity whether shielding is required in a particular system or not, until problems arise.
No, twisted pair would be an absolute must over that sort of distance. And as the other poster said, shielding would be highly recommended to prevent sleepless nights . I have seen such runs over UTP Cat5e, but not recommended in my opinion.
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. I have seen such runs over UTP Cat5e, but not recommended in my opinion. 
