I complete agree with "jdhar". Only once I have designed a board, where the digital and analog parts were neatly separated and it was possible to follow to the separate ground recommendation. In all other cases this recommendation seems to be a mockery, because analog and digital parts are usually mixed. So the best solution to reduce noises and interferences, even for a two layer board, is to make one (usually bottom) side a ground plane with as few other connection on it as possible. This can take a lot of time for a good design, but the result can be very good. You can have 27V PWM pulses and 12-bit ADC working on the same board.