OK, you have multiplexors 50 cm. apart. I don't know why you are using pull-up resistors in the first place. Is the source of the A, B, and C lines an open collector? Given all the capacitance you have on those lines, it is unlikely that the rising edge (cause by the pull-up resistors) is going to be very fast. If it is a slow edge, then you wont have substantial reflections in a mere 50 cm. of wire or traces. If you do have reflections, then I would be much more worried about the falling edge than the rising edge. The falling edge is coming from whatever device is sourcing the A, B, and C lines. It probably has an output impedance much lower than 4.7K, so it will pull the lines low a lot faster than the pull-up resistors will pull them high. As for what value of pull-up to use, that depends on why you need pull-ups.