From what I've seen, if you want to do a good job on
imager design in a non-imager-optimized process you
will probably have to break some rules and it may take
a few iterations to decide which ones.
Things like having poor quality oxides abutting the
depletion region give rise to excess noise (RTN is
a real nuisance because it's unfilterable). Field plates
and buried junctions are used to push the depletion
region away from such nastiness, but these are
"CMOS-abnormal" and might well flag in a vanilla
CMOS foundry DRC deck.
Amyway, if this is your deal, maybe you want to start
with a likely-looking cross section, figure out how to
make it so, and negotiate waivers when you're sure
there's nothing but "foundry unexpectedness" left in
the error-pile.