In my experience (30 years stale), the topology does not
really enter into it directly. But it can be constrained by
regulatory requirements, and attended by a lot of procedural
& documentary "stuff".
For example some regs may require galvanic isolation, EMI
output limits (radiated & conducted). Procedurally, your
eventual compliance certification and your insurer (and you
had best get insured, the plaintiff's bar will look at you for
any mishap) will require things like formal proof of stability
and thorough failure modes & effects analyses, to show
that there is no expectation (or missed expectation) of
failure. You will also be looking to design with components
that are up to "life support" requirements, something
that is specifically disclaimed on the majority of commercial
semiconductor products (go to the last page of the
datasheet, in the fine print). You will not like the pricing,
much, on what you -can- find. But you'd best specify
appropriate components, which means available @ grade.
Back in the day, we used what there was because the
semiconductor companies had more engineers and fewer
lawyers. But today is today, and tomorrow will be no
better.