one issue is that the microstrip line will heat up with ohmic losses. So a thicker copper thickness helps by reducing the line resistance.
Also there is a trade off. If you use a thick substrate the line can be wider, but there is more thermal resistance in the dielctric layer since it is now thicker. And vice versa.
Rogers TC series boards have a ceramic filled teflon dielectric that purportedly has lower thermal resistance. That would allow a thicker substrate with a wide line, but still not end up with too high a conductor temperature