Post simulation mismatch for the Gm/C filter

elonjia

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I designed a Gm/C filter, and for the pre-simulation using a schematic, it works well, but after I finish the layout (passing DRC and LVS), I find my circuit does not work well! Looks like there is a leakage path and my output is going down from the post-simulation result, what's the possible problem for this? Thanks!
 

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