The PIC will measure voltages ranging between ground (0V) and +VRef. Depending on the PIC type +Vref may be an internally generated voltage, VDD or a voltage supplied from another pin. Some PICs will also let you use a different lower (-Vref) voltage. You need to establish which configuration you are using so the range of ADC input is appropriate. What you can't do is measure a negative voltage, if a voltage lower than 0V or -Vref is fed into the PIC it could damge it.
Without seeing your schematic it's difficult to see exactly where your problem lies but in general, the rules are:
1. NO negaive voltages allowed at all on PIC pins.
2. If necessary, amplify the signal so it is a big as the ADC range (difference between +VRef and -VRef) so you get best reading resolution
3. To ensure the signal, amplified or not, never goes negaitve, apply a suitable offset to it to keep its upper and lower extremes withn +VRef and -VRef.
For example, assuming a 5V VDD and the ADC configured with -VRef = ground and +VRef = VDD, if your signal is +50mV to -50mV, amplify it by 50 times so it becomes -2.5V to +2.5V then offset it by +2.5V so it becomes 0V to 5V then feed it into the ADC. Your voltages will no doubt be different but hopefully that demonstrates the principle.
Brian.