first, you should know if your block is clock less or not.
I means if the inputs are only configurations coming from digital side, then there is not setup&hold constraints. You must modelisze with set_load, the input of the analog block to have the correct driver cell.
and for the outputs, that's the same idea with set_drive_cell, to indicate the equivalent drivers used the analog block, and then your digital design could estimate the correct driver.
You need to exchange some infos with your analog designer.
if your analog module is clocked, and the i/o is relative to this clock, then you could add set_[max¦min]_delay, and then during the Pnr/STA, this constraint will be checked.
To build a "fastest" liberty model, you could used the quick time model in Primetime.