Hi,
If GAIN is different at f1 and f2, you have to considere to different amplificator with two different gain and the same Noise Factor.
Noise is transpose by the mixer like signal frequency.
That's all.
With your system there is no problem with Friis' formula to calculate noise figure. In mixers use conversion loss, the IF frequency does not matter.
Make sure the second (upconverting) mixer is linear as Friis' formula only holds for linear circuits.