Did you ever hear the apocryphal story about Henry Ford (the founder of the american car manufactuer, Ford)? He sent someone round the scrap yeards to examine abandoned and broken old cars to find which parts only failed rarely, if at all.
His intention was to reduce the specification of those components which survived well, But you could do something similar from the opposite point of view, collect abandoned and failed SMPS units and note the frequency of each component's failures to determine which components fail most often.
There are some SMPSs in the workshop here which have been running continuously for over 20 years, day and night.
We had three units come in for repair recently which had been in use 24/7 for 15 years or longer, and all with SMPS failure. Replaced a few caps which had fallen below spec. and they were back in service. (One of them had other faults but not in the SMPS). I don't have the inclination but if I trawled through boxes of old PC PSUs I guess I'd come up with the same evidence.
Surely much of the answer to your question depends on what CAUSES of failure you want to anticipate in your design. Some units will be designed with better resilience to thermal problems than others, some will have over-rated components, bigger contact areas on their connectors, some will have mechanical strength and resistance to vibration, some just bigger & wider tracks on the boards. What are the causes of failure if they're not voltage, current, heat and stress?
If you tried to plan a generic resilient design, you could easily find yourself with 'the Henry Ford problem' - as soon as you increase the spec. of one common point of failure you will then find that the most common cause of failure is somewhere else!
Oh, I nearly forgot. The last factor for designs which fail is cost. Why do you think consumer products fail more readily than their industrial, medical and military equivalents?