Depends what types of circuits. Multisim an Proteus works well on general circuits but not so well on RF. I often use 3 types depending on the circuit. RF often require a non-linear simulator to get accurate results. For high frequencies a EM solver may be needed as well.
Though there are many circuit simulation softwares out there... I believe Orcad PSpice will be the most commonly used simulation tool for DC and low frequency applications... Agilent ADS will the best for RF