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Low level measurement techniques might be helpful :

[URL unfurl="true"]https://www.tek.com/en/documents/product-article/keithley-low-level-measurements-handbook---7th-edition[/URL]

Possible signal conditioning :

[URL unfurl="true"]https://www.ti.com/lit/an/sboa169b/sboa169b.pdf[/URL]

1) Consider a PSOC 5LP type of part, with 20 bit A/D and the following onboard resources (multiple copies in most cases) :

[ATTACH=full]198522[/ATTACH]

Has USBUART or SDCARD or display or other COM to get data.

Board to use CY8CKIT-059 unless you need a ton of I/O. its ~$15

IDE (PSOC Creator) and compiler free.

2) TIA appropriate but INA (instrumentation opamps) series might be better approach.

3) Best to do a sim of noise analysis for overall solution. And yes, lower input noise contributes

less to overall solution end to end error analysis.

4) You start with spec goals, eg. resolution, accuracy, INL and DNL and use that to screen for

parts.

Take a look at this - https://www.eevblog.com/projects/ucurrent/

Regards, Dana.