You need to describe what the numbered squares represent. One possibility is a differential amplifier composed of several transistors on the left and right half. But, which numbered squares are the left and right transistors?
In general, in order to guard against temperature gradients and doping profile gradients, you have to split the transistors in a totally symmetrical way.
For instance, in a two left two right arrangement, the top left and bottom right squares are one side and the other two squares contain the transistors for the other side of the differential pair.