As a first guess you can assume the current uniformally distributed along the loop wire. Use the radiation resistance formula for small loop antennas. As you tune it via the capacitance between the "high voltage" ends of the loop, a source in series with the loop will see this resistance (so it is a real value). In reality the impedance will be higher as your loop is not very short w.r.t. lambda, so current distribution will not be uniform, hence more far field radiation is produces.
Just let us assume a value of 5 Ohms. So when you interrupt the loop in the middle and put a source, its sees (for example) 5 Ohms. When feeding in the middle, the common mode voltage is lowest. You can use a standard L network to transform this to 50 Ohms at 2.45 GHz. Values will be in the range of 1 nH (series component), 4 pF (parallel to 50 Ohms source component).
So your 50 Ohms source will look into 4 pF (parallel) and a series L of 1 nH, this all in series with 5 Ohms radiation resistance. The capacitor can be just an SMD component. The inductor you make by increasing the capacitance between the high voltage ends a bit, this results in an inductive component in series with 5 Ohms. This has the same effect as making the loop somewhat longer to get 1 nH increase in inductance.
The other methods (inductive coupling and delta match) are mathematically very elaborate as you may to guess coupling coefficients via some very approximate calculations. I used both methods, but mostly I make a guess from experience, look to the S11 curve and based on that I know what to do.
You can reduce the far field radiation by dividing the tuning capacitance (end capacitance) over two opposite places. This makes the current distribution more uniform. I used this method in many inductive applications. It is also used in MRI antennas.