maximum frequency: Yes, I guess this is according your formula.what is the maximum frequency that the selected SPDT can go?
For read/write this frequency is useless. You nned to do a timing analysis for the complete communication path.when we want to read data from the chip.
You talk this all is bacuse of ADC...
Then I´d rather go with a common GND and shift the analog signal.
Mainly because "GND" should be the reference for all voltages. Isolating GND may reduce overall performance by introducing noise.
In detail it dependson the application´s requirement.
I like to differ between OPAMP and comparator.I am back to you again with this open-drain opamp, MCP6546
The given datasheet says:The data sheet is only referring to the open drain to be connected to the voltage level (VUP) that is higher or equal to VDD,
Looking at the post #8 schematic, I wonder why the two 3.3V supply voltages have been shifted against each other in this unsual way. The schematic doesn't show a detail that would require the offset. But may be it's hidden in the schematic.
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