Start with the output power of the laser as the maximum energy which can illuminate the photo-detector. Reduce this amount to take into consideration optical effects such as reflections, optical filtering and collecting area of the detector. Then, the photo-detector will have a specification called the "responsivity". Typically, this is in units of "Amperes per Watt" and is given for a range of wavelengths on a graph. For a silicon detector, a typical responsivity for green light is 0.8A/W. A red laser will have a lower responsivity. Look on the graph. Pick the wavelength of your laser. Then, multiply the optical power collected by the detector by the responsivity. This gives the resulting "photo-current" in the detector. From there, it is a matter of electronic design to convert the "photo-current" to the output. For example, let's say the maximum optical power is 5mW and 10% will be collected by the detector. This gives 0.5mW of optical power into the detector. From the responsivity graph, the laser is red and the responsivity is 0.5A/W. This gives a photocurrent of 0.5mWx0.5A/w = 0.25mA. One last point, the laser output will not be constant over time. For example, the output power may decrease as the laser ages. Take this into account in your design.
Detecting the blockage of a light beam can sometimes be as simple as using a "Schmitt Trigger Photo-IC". It has a digital output which can go right into a microcontroller. Search for this type of part.