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No, "The PA's reflection" is irrelevant no matter what.

The most important thing is that the PA be loaded with its optimal load impedance Zopt. The network connecting the PA to the antenna must transform the antenna impedance Za into Zopt.

The only reason the amplifier output impedance Zout might matter is if the antenna is a source of power when connected to the PA. For example, if the antenna is coupled to other antennas in a transmit array (I'm assuming this isn't the case for you).

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Could you give an example of how this depends on amplifier S22, either at a system level or component level?