(1) The trench needs to isolate the individual device, it
does not need to fill all of the space between devices.
There can be clear field with the trench only bounding
the edges where it abuts active devices.
(2) STI effects at the simulator level depend upon some
parameterization (and this, based on fitting - in turn based
on some substantial variations all being tested) in the
model. I have only seen intradevice strain effects attempted,
nothing for the trench width outside active area (although
indeed this does matter). The foundry is more interested
in consistency and keeping modeling effort to a minimum,
than enabling experimentation in a second- or third-order
layout effect.
It's not that it can't be done, it's that
(3) "upside" means some value for them, in making a mask
feature variable instead of fixed. The "downside" is more to
control, more complaints from users who took the geometry
away from normal and toward the design rule limit, more
work in characterizing a span where a single value would
suffice. This would be done in early process development,
a best-capability target found, and then that feature
"locked" - the variations should have been done for your
benefit already, you just don't get to see this, and any
excursion from the standard ought to be worse in some
way or other (presuming diligence on the foundry's part).
(4) You could fill with dummy trenches of compliant width
and space, but these would be only isolating nothing from
nothing (but, perhaps making more uniform lithographic
loading, etc.). If there is a maximum trench-trench space,
or rules for "dummy islands" / density, then filling with
some unit-trench features may be needed for rules
compliance. I doubt there is any electrical value though.
I suspect that some TCAD tools may let you model the
trench stress/strain on the device-region silicon and
the electrical outcomes, but also suspect this is a long
iterative research-y path. I would not expect first-pass,
first-principles success here; many nuances besides the
trench geometry at play (trench fill, thermal process
inputs, trench oxide interface qualities, ...).