I didn't have the chance to use a high/low MOSFET driver (as IR2101), so I know about the subject by analysing the circuit only.
When the high N-MOSFET is off, the pin Vs is likely close to ground (via the load) hence the Bootstrap Capacitor is charged (see pin Vb) at Vcc (actually at Vcc - Vdiode).
Then when it is on, the voltage of Vs will increase making the pin Vb also at a higher voltage than Vcc. This lets the voltage at pin HO for the gate be higher than Vcc too, and this ensures the turn ON of the N-MOSFET.
So at each transition of Vs from 0 to Vcc (ideally), the bootstrap capacitor is recharged to about (Vcc - Vdiode + Vcc).
Finding the optimimum value for this capacitor is likely related to Vcc and load for a few.
I never did its calculation (since I didn't built your circuit yet) but there are, for sure, some good refrences for it.