If you think about the blocker, it's at a much higher level then the desired signal on channel. You need to make sure that your receiver has enough filtering so that when you reach the ADC, the blocker is at a low enough level that you have sufficient dynamic range for both the desired signal and the (Filter attenuated) blocker. A Second order effect is that the Phase Noise of the LO at the Blocker offset will also cause an interfering signal, so you have to budget for this.