in terms of simulator -
Both the pullup and pulldown are always to be used. Actually, all the I-V tables are always used. Any standard simulator with IBIS support will do that. So, for example, if there is a lot of leakage in pulldown, that effect will be show up in the result.
The V-t curves are there for only one simulation (and only one input). However, if u give a different input slew, the simulator should beable to handle that and give u relatively accurate result using the I-V tables. So, in a way I-V and V-t tables complement each other.