Are you obtaining the data from a dispersion simulation, or a driven simulation? The dispersion will directly give you Beta as a function of frequency, but if your structure isn't continuous or periodic this wouldn't be the most appropriate.
You can extract Beta from the scattering parameters of a driven simulation through assuming homogenization (i,e, convert the scattering parameters to something like ABCD parameters, and Beta will be imag{acos(A)/l}, where l is the length of your homogenized line).
You can take the derivative in either of these cases by using the "deriv" function in the output variables (HFSS->Results->Output Variables)