What it actually matters is the input-referred offset. Offset actually depends on the common mode input voltage. When you say that your initial offset is -0.3mV, respect to what? Is it input- or output-referred? What input voltage? What's the configuration you use to determine the offset? Is your input voltage within the valid common mode range? Are you talking about systematic or random offset? Systematic offset depends on your design and bias conditions. Random offset depends on transistor mismatch, which in turns depends on transistors sizes and bias. Analize all this and calculate what is your spected offset.
To see the result of the random offset, you need to perform Monte Carlo simulations? Do tou have a proper mismatch model? Do you simulate in all posible corners?