I have made LDMOS with no additional masks but this is
in a technology where I have a whole raft of body implants
to manipulate.
If you use a N-well, non-self-aligned drain you can get to
a decent breakdown. You'll be breaking a bunch of ground
rules no doubt, unless you're not the first guy doing this
at foundry*flow. You will have some learning to do in the
field plate department (a second poly would be sweet,
aluminum will serve but its work function is probably not
ideal).
In 0.5um "3.3V" technology, I've seen longer (1um) channel
and dense body ties get me past 6V. I've also seen a lot of
people struggle to get reliable 5V +5% @ 0.6um, and so I
doubt your 0.5um, 5V process is for real. Maybe it depends
on what you consider "for real".