Yes, you can extract all of RLCK [Resistance, Capacitance, Self-Inductance, and Mutual-Inductance] of all interconnect wires[for smaller blocks], or selective nets[for larger designs], by using Cadence QRC extraction tool. Inductance extraction is usually required for for higher frequencies - I am aware of Analog Designers doing so from 2GHz - to - 80 GHz using Cadence QRC.
Yes, Mutual Inductance is more important than self. These LK may not be negligible. The reason Inductance is not considered at times - extraction and analysis of Inductance is expensive, w.r.t. time & money, not every design can afford so, and various margins, over-design factors pays that part. However, for very high-frequency - they do LK extraction.
In most cases, they use PEEC & Ladder-network - that also includes "skin-effect" and "proximity-effect", the bad side-effect is, the result netlist size, as well as simulation runtime increases dramatically. So, there always remains a conscious tradeoff between how-much we need to extract, to get meaningful result within some specified time.
Users do not extract LK [self&mutual inductance] - over the whole chip, rather they choose selective user-region/s [RF design needs experience - to choose appropriate regions].
For a clock at 2.4GHz, a decent presence of the third harmonic [7.2 GHz] makes sense for some designers - so during s-parameter analysis, while doing frequency sweep they check both the value and phase beyond 3x the design frequency as well..