As I never did such focusing, I would only guess. But you have the real antenna and lens, so go on and experiment!
Lenses have simple forms, concave or convex; so it is easy to model "rays". With a Cassegrain system, the field close to the aperture is not easy to model. Given that the beam and sidelobes form along the axis up to the far-field zone, I think the safest way would be to install the antenna and a movable(in azimuth ) receiver at >10 meters, and then put the lens between the two, closer to the receiver. Then record the beam form and sidelobe level, and repeat for several distances between the Cassegrain and the lens.
Again, if you are lucky, you find an optimum position.
You can also generate the ray map of your lens, and locate it so it focuses the parallel rays from the Cassegrain to the receive point. Then you can confirm the ray map with pattern measurement.
Modifying the finished expensive Cassegrain would be the last resort to try.