how to calculate control impedance

[DNA2683]

hi all

I have a board with the following stack up:
L1 -signal
L2 -plan
L3 -signal
L4 -signal
L5 -plan
L6 -signal

I'm using the Saturn calculator, my question is if i have a trace on L3 and i want to calculate his impedance to I need to refer to this signal as a microstrip embed ? or as striplins asym?

I'm trying to figure it up if only the L2 plan effect on the trace on L3 impedance or also the plan on L5 effect the impedance of the trace on L3

thanks

 

[FvM]

It should be treated as asymmetric stripline. Problem is that L4 traces also affect L3 impedances and vice versa. Preferably L3 and L4 are routed orthogonal.

 

[DNA2683]

It should be treated as asymmetric stripline. Problem is that L4 traces also affect L3 impedances and vice versa. Preferably L3 and L4 are routed orthogonal.

Thank you for your answer.
What do you mean when you say L3 and L4 are routed orthogonal. It mean that I need to avoid parallel traces between L3 and L4?