will this circuit work? All NPN transistor switching circuits I have seen switch higher voltages from lower voltages (at base). Here, I need to switch 3.3V with 12V. i.e When no voltage at base Vout should be high (3.3V) and when 12V at base Vout should be Low (0V).
That circuit should work fine. Since the normal rule-of-thumb is to use a base current of at least 1/10 of the collector current to saturate the transistor, any base resistor (R75) of 330k or less will work.