Hi,
As above, but if still nothing working;
Ensure MPlab is closed down.
Ensure nothing is connected to your Pk2 output socket.
Start PK2 V2.61 program.
According to your earlier posts you do get the 'Pickit2 Connected' so go to the Tools Menu and select TroubleShoot.
This allows you to check Vdd, VPP at around 12v and PGC / PGD.
Do not try and adjust anything, just see what Vdd and Vpp are reporting.
Let us know what results, if any, you get.
? Did you use any parts with different values to those shown on the circuit diagram ?
For PGD/C manually select and measure their HIGH and LOW voltages, typically 0.0V and 4.7V