I know that distinctive angry hissing sound.....
Its when the feedback loop goes absolutely crazy outputting a nasty jittery intermittent output, especially with no load on the supply.
The most usual cause is not the feedback loop, but the PWM generator.
If there is a minimum duty cycle at which it just winks off, instead of gracefully falling right down to zero, you can have the situation where one (minimum) flyback pulse is still far too much energy.
The loop then shuts down, and starts back up some indeterminate time later producing one, or more often several output pulses, then shutting down again. This can be very fast and unstable, and sound like a broadband hiss.
A simple fix is to add a bleeder resistor to the output to add just enough load to make the problem go away.
A more complex solution might be to artificially reduce the duty cycle very slightly with a slow on, fast off, circuit. That may require an extra gate driver chip after the control chip. Its a brute force solution.
Last suggestion might be to try a different controller. That one is supposed to go down to zero duty cycle, and it probably does.
But what if it only reduces linearly down to say 5% duty cycle then winks off ?
It may not be capable of creating a 4% or 1% duty cycle.
The guy that wrote the specification is only saying it CAN go right to zero, not that it will have linear control right down to zero.
So check, you might find (for example) that you can reduce the duty cycle manually with a potentiometer down to say 500 nS, then it abruptly shuts off.