3d hyperlynx
If your designs haven't high speed buses or signals, you probably never ever listen about HyperLynx.
If you have 33MHz PCI bus you can still have successful design without verification.
But if you have 2 or more SDRAM chips running over 70-80MHz, you are in the "dark side" and "things" become happened. Of course, you can still have working designs, but is possible to reach falls from board to board (manufacturing tolerances) or from chip supplier to chip supplier.
If you have complex boards with high speed buses (one or more), HyperLynx must be at least pre-route constrains determination.
So, the answer is "depend of your designs".