With careful PCB routing, parts placement (don't put uC next right to the PLL's VCO circuit for instance without at least some board copper there) and proper Vcc and Vdd bypasssing and use of a separate regulator to power the PLL and Uc, should not have much of an issue for your application ... on-channel noise and spurious are not the issue with a uC controlled little transmitter like this, it is when one tunes off-channel and one picks up products 'mixed' with the uC clock and various other 'rates' and clocks (that might be down only 30 dB from carrier) that it might become an issue, especially if one has to meet spectral purity requirements. For your own use, I would not be as concerned (unless you plan to boost output to 50 Watts that is!)
With the radio spectrum, it is a good idea to be clean and not bother adjacent stations (your neighbors, so to speak) lest they make/file an FCC complaint.
Jim