What is accuracy you are seeking for the measurement ?
Once you get measurement what do you want to do with it ?
Regards, Dana
- - - Updated - - -
You could use a dirtball cheap processor with ADC with differential front end.
Just an 8 pin part with a cap to bypass its supply rail. Anywhere from 8 to
20 bit accuracy, the latter in bigger packages. Some with precision Vref
onboard, some Vref is supply pin.
Note R divider still external and needed for both comparison supplies.
It all depends on what the overall function and accuracy of the design requirements are.
Regards, Dana.