If you want to simulate your circuit then you'll have to build a complete SPICE model for this circuit and attach it to its schematic symbol. Since it's a very complex IC, it will cost you many days (unless you're an experienced SPICE modeler) and it won't be even close to the part's actual performance.
If you only want to have a model for signal integrity simulation then you could simplify it: all inputs can be modeled as resistors and capacitors to ground (to give these pins a finite input impedance and parasitic capacitance), and outputs can be modeled as Norton/Thevenin equivalents using coupled voltage sources or current sources. This is a lot faster, and may just as well suit your needs.