Usaually the cascaded system simulator ask for 3 parameters, namely, Gain, Noise Figure, and Intercept Point.
The user try useful that only 3 parameters (and not more) are asked.
Of course, one assumption is the perfect impedence matching.
But... if you'll change the Generator reflection coefficient, the noise figure will change ( this is due to the noise modelling of the 2 port network).
In this case the noise parameters needed for calculation will rise from 1 to 4 (NFmin, ReΓopt, ImΓopt, Rn) so the calculator will became un-useful.