Never random - what good would that do?
It means there are three or more bytes:
Byte 1: is the device ID according to the I2C spec, it selects the device in case there are other I2C devices on the same bus.
Byte 2: having selected the device with byte 1, this selects which register inside that device the following data is to go to.
Byte 3 and onwards: the actual data to be written to the selected register in the selected device.
Some registers need a single byte, some need several bytes so after byte 1 and 2, you send as many as required.
Brian.