I've successfully designed sub-threshold opamps, OTAs, voltage regulators, references (current and voltage), and ADCs.
The main problems with subthreshold region are speed (very low current = serious speed issues), and the exponential current gain can throw power higher than desired at points (eg. one of my voltage references used 30nW of power at 20°C, but 100nW of power at 60°C, 170nW at 100°C).
Basically, the first order approximation of the weak inversion region is identical to that of a BJT.
Does that help at all?