This topic generates a LOT of discussion. But here's what I do (for what it's worth).
1) You can split your power (VCC) plane into several sections, one for analog, and one for digital
2) I would be more inclined to separate my analog/digital sections across the board rather than top and bottom
3) I put all my regulators in one area, but try to put the analog ones closer to the analog power plane
4) I use a single ground plane (I know, I know, this is probably the biggest area of discussion), but you can add cutouts to the plane to 'steer' ground currents.
5) The fact that you imply you are using switching regulators says that you need to pay additional attention to the tons of noise they generate and how that will affect your analog circuitry.
Probably the best advice I can give is to actually THINK about how currents are going to flow on the board. The WHOLE problem comes down to unwanted(digital) current paths through your sensitive analog circuitry. If you can lay out your board so that the digital ground currents flow back to the regulator without having to run through the analog ground path, you'll be ok.
Hope this helps.
Barry