Now I have a little better idea about your circuit. Your analog circuit is not high speed as you only use SPI bus. I don't think you need to split into two boards. You still have digital on the analog as you have the SPI interface.
But if that's what you want, read my original post again. It is the proximity that is very important. Digital return current on the ground plane stay closely under the trace, so make sure you have all the digital signals stay clear of the analog circuit. Have the analog input and circuit on one side of the board, all the digital circuit on the other side, the SPI come out on the side of the digital circuit.
I take that you plug the small analog board onto the digital board by a connector. Make sure you have plenty of ground pins, each pin accompanies one signal of the SPI. You don't need to add any more ground connection after that. So you have input analog signal and ground, going through the analog board, then ground connects through the SPI connector to the digital board.
Again, you don't need to split board. I pack dense surface mount mixed signal circuits together all the time. I worked with very low level signals of uV range. On very sensitive circuit, I use 6 layer boards, I have two ground layers and put the split power plane sandwiched between the two ground layers so I don't have to worry about the split power plane. The two ground planes are continuous, no splitting. My last design was a mixed signal board with 16 channel 400MHz bandwidth each with gain of about 50 to 100. Converting into pulses by comparators and feed into FIFO so slow down the read out speed. All in a 12"X10" board.
Lastly and most important.............Are you an engineer or pcb designer? If you are pcb designer, let the engineer make the decision. It's really not your problem, let the engineer decide and it'll be his responsibility. I am talking to you as an engineer and I make my decision and I am responsible 100% for my board. As a pcb designer, you are not responsible for this. I am not a pcb designer, I just layout my own boards as it is not efficient to work with a pcb designer in very critical mixed signal boards. AND ultimately, I am 100% responsible for the board.