FvM has the correct answer.
With an N-ch MOSFET, the gate drive to turn on MOSFET must go at least 10v above its source.
The 2110 uses a bootstrap upper driver capacitor supply. The 'ground' side of the upper stage is the Vs pin. It rises up when a lower MOSFET is turned off. C1 capacitor must be recharged periodically to re-establish the voltage across the bootstrap capacitor. This is normally done in a push-pull stacked MOSFET pair when the bottom MOSFET is turned on. The diode passes the capacitor recharge current.
The driver must work with a continously chopping output push-pull configuration otherwise the upper driver power supply will be depleted.
You could provide a separate isolated 12 to 15v supply across C1 to provide continuous DC supply to upper driver of 2110. It must be isolated so it can float up and down with your external MOSFET source voltage.