What you are missing is signal conditioning. Also even 24 bit ADCs don't have 24 bit noise specs, so their outputs fluctuate, they're 24 bits because they're usually delta sigma and it's easy to give out 24 bits and it's sometimes beneficial in digital processing that comes afterwards.
It's not always a good idea to give signal close to LSB of a data converter, because that signal is going to get lost anyway. What is usually done is that they amplify the small signal using a dedicated super low noise amplifier, so that the data converter noise won't be an issue.
Generally resolution is needed if you need more steps in data conversion, it's not for sensing very small signals. This sounds stupid of course, but what I mean is, if you are interested in having 2^24 steps in between 100-500 nV use 24 bit ADC, not because 24 bit ADC's LSB is in nV range. Your input signal must be amplified anyways.
Edit: Wait, I'm sorry, I misunderstood your question. You actually want 100-500 nV resolution, I thought you wanted to measure a signal with 100-500 nV amplitude. Sorry about that. But still signal conditioning is the answer. Zoom into the range you are interested in, amplify, send it to data converter. There is no real 24 bit data converter, and even the most stupid things will add noise more than 100-500 nV, so you need to modify signal a bit anyways.