If you don't need isolation you don't need isolation.
But the problem is you have a high boost factor of about 20. This demands extreme duty cycle (~95%). Sometimes you turn to a transformer topology so the transformer can do the step-up for you (flyback for example).
There are many "Nixie" power supplies which increase a low voltage source (usually 12 volts), to the Nixie's anode voltage, which is anywhere from 170 to 250 volts.
And they use the exact same topology shown. Of course, current consumption is about a dozen milliamps or so.
I would advise that dc-dc converters with output voltages in excess of 60Vdc should incorporate transformer for the sake of safety and regulatory obligations. Battery-operated appliances should have a voltage rating not exceeding 75Vdc which is the maximum.
I would advise that dc-dc converters with output voltages in excess of 60Vdc should incorporate transformer for the sake of safety and regulatory obligations. Battery-operated appliances should have a voltage rating not exceeding 75Vdc which is the maximum.
This can't be a serious safety assessment without knowing any application details. Is the high voltage exposed to the outside, are there current limiting means? Isolation may or may not increase safety, depending on the connected circuit.
This can't be a serious safety assessment without knowing any application details. Is the high voltage exposed to the outside, are there current limiting means? Isolation may or may not increase safety, depending on the connected circuit.